Virtualenvwrapper
Just curious - why no mention of using virtualenvwrapper?
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Answers
Virtualenvwrapper is great but it's more useful on a box that you'll be developing on for a long time instead of something like a vagrantbox that's meant to be thrown away.
That said, if you want to use virtualenvwrapper, go for it. Nothing will be different other than how you activate the virtualenv.